Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 9/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CBLB | Q13191 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185357 | 1.00 | STING1 (1.00) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL29784554 | 0.95 | STING1 (0.90) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL27185519 | 0.91 | STING1 (0.83) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL29784332 | 0.91 | STING1 (0.83) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL30829680 | 0.74 | STING1 (1.00) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL27185485 | 0.74 | STING1 (1.00) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL28287812 | 0.73 | KDM4E (0.62) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL21567969 | 0.72 | HSD17B10 (0.71) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL309036 | 0.71 | IRAK4 (0.58) | STING1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL31294187 | 0.71 | KDM4E (0.59) | STING1KDM4EHSD17B10HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169921-A1 | BENZOFURAN COMPOUNDS AS STING AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-11 | — | — | WO | claimed |
| WO-2022169921-A1 | BENZOFURAN COMPOUNDS AS STING AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-11 | — | — | WO | disclosed |