Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | BRD2 | P25440 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279445 | 1.00 | PLA2G2A (0.53) | PLA2G2ABRD4BRD2CREBBPPLA2G4B | |
| SCHEMBL2655120 | 0.88 | PLA2G2A (0.65) | PLA2G2ABRD4BRD2CREBBPPLA2G4B | |
| SCHEMBL3184334 | 0.88 | PLA2G2A (0.59) | PLA2G2ABRD4BRD2CREBBPPLA2G4B | |
| SCHEMBL14297573 | 0.84 | PLA2G2A (0.71) | PLA2G2APLA2G4BTP53TSHRKMT2A | |
| SCHEMBL17823602 | 0.83 | PLA2G2A (0.55) | PLA2G2APLA2G4BTP53PKMTSHR | |
| SCHEMBL30091972 | 0.83 | PLA2G2A (0.55) | PLA2G2APLA2G4BTP53PKMTSHR | |
| SCHEMBL2176490 | 0.83 | NR1H4 (0.48) | PLA2G2ARXRARXRBKMT2AMEN1 | |
| SCHEMBL5051460 | 0.82 | GSK3B (0.44) | TP53TSHRKMT2AHSD17B10MEN1 | |
| SCHEMBL29173958 | 0.82 | PARP10 (0.43) | BRD4BRD2CREBBPTP53TSHR | |
| SCHEMBL288382 | 0.82 | BRD4 (0.53) | BRD4BRD2CREBBPTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | MAGI3, PYM1, MAG | PLA2G2A 646/4885BRD4 1025/4885BRD2 951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.