Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.53 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.53 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 2/20 | 0.50 |
| ▸ | RXRB | P28702 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22442328 | 1.00 | AKR1C3 (0.62) | AKR1C3AKR1C2SRD5A2IP6K1IP6K3 | |
| SCHEMBL29771953 | 0.87 | CNR2 (0.58) | AKR1C3AKR1C2SRD5A2IP6K1IP6K3 | |
| SCHEMBL179120 | 0.84 | SLC1A3 (0.54) | AKR1C3AKR1C2SRD5A2IP6K1IP6K3 | |
| SCHEMBL505879 | 0.81 | AKR1C3 (0.56) | AKR1C3AKR1C2MEN1KMT2AKDM4E | |
| SCHEMBL2744459 | 0.81 | SLC1A3 (0.54) | AKR1C3AKR1C2SRD5A2IP6K1IP6K3 | |
| SCHEMBL177461 | 0.81 | RXRA (0.63) | AKR1C3AKR1C2SRD5A2IP6K1IP6K3 | |
| SCHEMBL30393660 | 0.81 | RXRA (0.63) | AKR1C3AKR1C2SRD5A2IP6K1IP6K3 | |
| SCHEMBL2041007 | 0.81 | RARB (0.56) | AKR1C3AKR1C2MEN1KMT2AALDH1A1 | |
| SCHEMBL29473809 | 0.81 | RARB (0.56) | AKR1C3AKR1C2MEN1KMT2AALDH1A1 | |
| SCHEMBL22190055 | 0.81 | IP6K1 (0.49) | AKR1C3AKR1C2SRD5A2IP6K1IP6K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | MAGI3, PYM1, MAG | AKR1C3 2867/4885AKR1C2 3475/4885SRD5A2 4796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.