Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.51 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4550826 | 1.00 | PDE2A (0.51) | PDE2AIDO1TDO2HTR2AHTR2C | |
| SCHEMBL21801027 | 1.00 | PDE2A (0.51) | PDE2AIDO1TDO2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL2714210 | 0.98 | IDO1 (0.53) | PDE2AIDO1TDO2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL21199585 | 0.98 | IDO1 (0.53) | PDE2AIDO1TDO2HTR2AHTR2C | |
| SCHEMBL29685925 | 0.85 | PDE2A (0.66) | PDE2AIDO1TDO2HTR2AHTR2C | |
| SCHEMBL4233776 | 0.85 | PDE2A (0.66) | PDE2AIDO1TDO2HTR2AHTR2C | |
| SCHEMBL30557838 | 0.85 | PDE2A (0.66) | PDE2AIDO1TDO2HTR2AHTR2C | |
| SCHEMBL4550763 | 0.85 | PDE2A (0.66) | PDE2AIDO1TDO2HTR2AHTR2C | |
| SCHEMBL14120778 | 0.85 | PDE2A (0.66) | PDE2AIDO1TDO2HTR2AHTR2C | |
| SCHEMBL8074637 | 0.84 | PDE2A (0.55) | PDE2AIDO1TDO2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135648-B | Dihydronaphthyridones, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-115135648-A | Dihydronaphthyridinone compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-110520423-B | Aminotriazolopyridines as kinase inhibitors | 百时美施贵宝公司 | 2022-08-23 | — | — | CN | disclosed |