Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.47 |
| ▸ | MAX | P61244 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342938 | 0.85 | MYC (0.55) | AKR1C3AKR1C2AKR1C1ALDH1A1MYC | |
| SCHEMBL30892476 | 0.85 | MYC (0.55) | AKR1C3AKR1C2AKR1C1ALDH1A1MYC | |
| SCHEMBL2146139 | 0.84 | HTT (0.58) | ALDH1A1MYCMAXMEN1KMT2A | |
| SCHEMBL30082879 | 0.81 | MYC (0.59) | AKR1C3AKR1C2AKR1C1ALDH1A1MYC | |
| SCHEMBL527105 | 0.81 | MYC (0.59) | AKR1C3AKR1C2AKR1C1ALDH1A1MYC | |
| SCHEMBL11704439 | 0.81 | MYC (0.55) | AKR1C3AKR1C2AKR1C1ALDH1A1MYC | |
| SCHEMBL24100292 | 0.80 | AR (0.56) | AKR1C3AKR1C2AKR1C1ALDH1A1MYC | |
| SCHEMBL10319262 | 0.79 | MAPT (0.47) | AKR1C3AKR1C2AKR1C1ALDH1A1MYC | |
| SCHEMBL9579844 | 0.79 | MAPT (0.48) | AKR1C3AKR1C2AKR1C1ALDH1A1MYC | |
| SCHEMBL12114408 | 0.78 | MAPT (0.50) | ALDH1A1MYCMAXMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781459-B2 | Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-08-24 | — | — | US | disclosed |
| US-20070088083-A1 | CARBOXYALKOXY-SUBSTITUTED ACYL-CARBOXYPHENYLUREA DERIVATIVES AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-04-19 | — | — | US | disclosed |
| US-20040157922-A1 | Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157922-A1 | Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments | CPS1, DPP4, ACAA2 | AKR1C3 1058/4885AKR1C2 694/4885AKR1C1 990/4885 |
| US-20070088083-A1 | CARBOXYALKOXY-SUBSTITUTED ACYL-CARBOXYPHENYLUREA DERIVATIVES AND THEIR USE AS MEDICAMENTS | CPS1, ACAA2, GLS | AKR1C3 1172/4885AKR1C2 806/4885AKR1C1 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.