Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 6/20 | 0.74 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.34 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24183636 | 1.00 | ADRA2C (0.74) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL30398477 | 1.00 | ADRA2C (0.74) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL29787277 | 0.91 | ADRA2C (0.79) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL24183645 | 0.91 | ADRA2C (0.79) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL29787312 | 0.91 | ADRA2C (0.79) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL25437600 | 0.91 | ADRA2C (0.79) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL25425779 | 0.91 | ADRA2C (0.79) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL30398367 | 0.91 | ADRA2C (0.79) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL29787323 | 0.91 | ADRA2C (0.79) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 | |
| SCHEMBL24183496 | 0.90 | ADRA2C (0.75) | ADRA2CHRH3MAPK8TMPRSS15ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4175954-A1 | COMBINATION OF AN ALPHA2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA | Bayer Aktiengesellschaft (DE) | 2023-05-10 | — | — | EP | disclosed |
| EP-4021905-A1 | INHIBITORS OF ADRENORECEPTOR ADRAC2 | Bayer Aktiengesellschaft (DE) | 2022-07-06 | — | — | EP | disclosed |