Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | CASP7 | P55210 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24596264 | 1.00 | MAT2A (0.48) | MAT2AALDH1A1CYP3A4HSD17B10USP2 | |
| SCHEMBL29789866 | 0.89 | MAT2A (0.46) | MAT2AALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL26631707 | 0.89 | MAT2A (0.46) | MAT2AALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24596201 | 0.87 | MAT2A (0.49) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29789948 | 0.87 | MAT2A (0.49) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30611291 | 0.87 | PDE4A (0.52) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24596154 | 0.87 | PDE4A (0.52) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24596222 | 0.83 | MAT2A (0.52) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29789914 | 0.83 | MAT2A (0.52) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24596231 | 0.82 | MAT2A (0.48) | MAT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022143864-A1 | TRICYCLIC COMPOUND AND USE THEREOF | 江苏先声药业有限公司 | 2022-07-07 | — | — | WO | disclosed |