Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 1.00 |
| ▸ | DHODH | Q02127 | 3/20 | 0.80 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.72 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.71 |
| ▸ | PLK4 | O00444 | 1/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.71 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.71 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.71 |
| ▸ | PIM1 | P11309 | 1/20 | 0.71 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.71 |
| ▸ | PRKACA | P17612 | 1/20 | 0.71 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.71 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.71 |
| ▸ | CLK2 | P49760 | 1/20 | 0.71 |
| ▸ | GSK3A | P49840 | 1/20 | 0.71 |
| ▸ | PRKX | P51817 | 1/20 | 0.71 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28840590 | 1.00 | PARP1 (1.00) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL505358 | 0.89 | PARP1 (1.00) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL458836 | 0.89 | PARP1 (1.00) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL29412034 | 0.89 | PARP1 (1.00) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL2299805 | 0.88 | PARP1 (0.79) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL7316597 | 0.86 | PARP1 (1.00) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL423551 | 0.86 | PARP1 (1.00) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL29380664 | 0.86 | PARP1 (1.00) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL3159315 | 0.85 | PARP1 (0.78) | PARP1DHODHPARP2CHEK2PLK4 | |
| SCHEMBL3341660 | 0.85 | PARP1 (1.00) | PARP1DHODHPARP2CHEK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025042769-A1 | COMPOUNDS AND METHODS FOR INHIBITING POLY(ADP-RIBOSE) POLYMERASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2025-02-27 | — | — | WO | disclosed |
| CN-114907269-A | Benzimidazole-4-carboxamide derivative with piperazine as connecting group | 南华大学 | 2022-08-16 | — | — | CN | disclosed |