Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 1.00 |
| ▸ | DHODH | Q02127 | 4/20 | 0.94 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.79 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.79 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.79 |
| ▸ | PLK4 | O00444 | 1/20 | 0.79 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.79 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.79 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.79 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.79 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.79 |
| ▸ | PIM1 | P11309 | 1/20 | 0.79 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.79 |
| ▸ | PRKACA | P17612 | 1/20 | 0.79 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.79 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.79 |
| ▸ | CLK2 | P49760 | 1/20 | 0.79 |
| ▸ | GSK3A | P49840 | 1/20 | 0.79 |
| ▸ | PRKX | P51817 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412034 | 1.00 | PARP1 (1.00) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL505358 | 0.97 | PARP1 (1.00) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL29790551 | 0.89 | PARP1 (1.00) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL28840590 | 0.89 | PARP1 (1.00) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL7316597 | 0.88 | PARP1 (1.00) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL29380664 | 0.88 | PARP1 (1.00) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL6809991 | 0.88 | PKN1 (1.00) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL423551 | 0.88 | PARP1 (1.00) | PARP1DHODHPKN1PKN2CHEK2 | |
| SCHEMBL1298432 | 0.88 | DHODH (0.94) | PARP1DHODH | |
| SCHEMBL3159315 | 0.87 | PARP1 (0.78) | PARP1DHODHPKN1PKN2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022026-A1 | METHOD OF TREATING CANCER | ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) | 2012-01-26 | — | — | US | claimed |
| EP-2387403-A1 | METHOD OF TREATING CANCER | Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) | 2011-11-23 | — | — | EP | claimed |
| US-20110253692-A1 | Electrical heater for vehicle windshields and windows | SCHAUBLE RICHARD EGON | 2011-10-20 | — | — | US | claimed |
| WO-2010082821-A1 | METHOD OF TREATING CANCER | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2010-07-22 | — | — | WO | claimed |
| EP-0841924-B1 | BENZIMIDAZOLE COMPOUNDS | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-10-02 | — | — | EP | claimed |
| US-6310082-B1 | PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE POLY(ADP-RIBOSE)POLYMERASE ENZYME INHIBITING AMOUNT OF BENZIMIDAZOLE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT AND/OR PRO-DRUG FORM THEREOF, WITH ACCEPTABLE CARRIER | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-30 | — | — | US | claimed |
| EP-0841924-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-05-20 | — | — | EP | claimed |
| WO-1997004771-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1997-02-13 | — | — | WO | claimed |
| US-20240105279-A1 | METHODS AND SYSTEMS EMPLOYING TARGETED NEXT GENERATION SEQUENCING FOR CLASSIFYING A TUMOR SAMPLE AS HAVING A LEVEL OF HOMOLOGOUS RECOMBINATION DEFICIENCY SIMILAR TO THAT ASSOCIATED WITH MUTATIONS IN BRCA1 OR BRCA2 GENES | Genomic Testing Cooperative, LCA (US) | 2024-03-28 | — | — | US | disclosed |
| CN-107915748-B | Preparation method of 4- (tert-butyl) -1-phenyl-imidazo [4,5,1-kl ] phenoxazine | 华东师范大学 | 2020-05-12 | — | — | CN | disclosed |
| CN-107915748-A | A kind of preparation method of 4 (tert-butyl group) 1 phenylimidazoles simultaneously [4,5,1 kl] phenoxazine | 华东师范大学 | 2018-04-17 | — | — | CN | disclosed |
| EP-1391457-B1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | ABBVIE DEUTSCHLAND (DE) | 2013-12-25 | — | — | EP | disclosed |
| US-8288387-B2 | Napthalimide-benzimidazole hybrids as potential antitumor agents and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-10-16 | — | — | US | disclosed |
| US-20120022026-A1 | METHOD OF TREATING CANCER | ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) | 2012-01-26 | — | — | US | disclosed |
| US-6100283-A | PRODRUG PHOSPHATE DERIVATIVE FOR POLY (ADP-RIBOSE) POLYMERASE ENZYME INHIBITOR FOR ADMINISTERING IN CONJUNCTION WITH ANTITUMOR DRUG OR RADIOTHERAPY | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-08-08 | — | — | US | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |
| WO-2000029384-A1 | 2-PHENYLBENZIMIDAZOLES AND 2-PHENYLINDOLES, AND PRODUCTION AND USE THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-25 | — | — | WO | disclosed |
| WO-2000026192-A1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-11 | — | — | WO | disclosed |
| EP-0841924-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004771-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1997-02-13 | — | — | WO | disclosed |