Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | CD44 | P16070 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3873719 | 1.00 | CYP3A4 (0.55) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL457125 | 0.86 | CYP3A4 (0.52) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL29838774 | 0.86 | ALDH1A1 (0.40) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL28606707 | 0.86 | CYP3A4 (0.60) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL29358157 | 0.86 | CYP3A4 (0.52) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL16660691 | 0.86 | CYP3A4 (0.46) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL1479690 | 0.86 | ALDH1A1 (0.40) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL1548535 | 0.80 | CYP3A4 (0.60) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL717789 | 0.79 | ALDH1A1 (0.36) | CYP3A4TSHRMAPK1ALDH1A1CD44 | |
| SCHEMBL5390700 | 0.79 | CD44 (0.65) | CYP3A4TSHRMAPK1ALDH1A1CD44 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117242060-A | Isoindolinone compounds | 蒙特罗萨医疗公司 | 2023-12-15 | — | — | CN | disclosed |
| EP-4277901-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics, Inc. (US) | 2023-11-22 | — | — | EP | disclosed |
| WO-2022152821-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-07-21 | — | — | WO | disclosed |