Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 3/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.59 |
| ▸ | PRKCI | P41743 | 6/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | GRK6 | P43250 | 1/20 | 0.45 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.45 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.45 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22944042 | 1.00 | GRK2 (0.65) | GRK2ROCK1ROCK2PRKCICYP3A4 | |
| SCHEMBL22944014 | 0.84 | ROCK2 (0.70) | GRK2ROCK1ROCK2PRKCIAURKA | |
| SCHEMBL29791519 | 0.84 | ROCK2 (0.70) | GRK2ROCK1ROCK2PRKCIAURKA | |
| SCHEMBL22944554 | 0.79 | GRK2 (1.00) | GRK2ROCK1ROCK2AURKAPRKCB | |
| SCHEMBL29791516 | 0.79 | GRK2 (1.00) | GRK2ROCK1ROCK2AURKAPRKCB | |
| SCHEMBL22944248 | 0.72 | ROCK1 (0.66) | GRK2ROCK1ROCK2AURKAPRKCB | |
| SCHEMBL22943511 | 0.71 | GRK2 (1.00) | GRK2ROCK1ROCK2AURKAPRKCB | |
| SCHEMBL13362788 | 0.71 | ROCK2 (0.67) | GRK2ROCK1ROCK2AURKAPRKCB | |
| SCHEMBL858227 | 0.68 | BRD4 (0.75) | ROCK1PRKCICYP3A4CYP2D6PRKCA | |
| SCHEMBL18767082 | 0.66 | IKBKB (0.52) | ROCK1PRKCIGRK5BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220267298-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL AS GRK2 INHIBITORS | JANSSEN RESEARCH & DEVELOPMENT, LLC | 2022-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220267298-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL AS GRK2 INHIBITORS | GRK2, GRK4, GRK3 | GRK2 1/4885ROCK1 803/4885ROCK2 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.