Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.36 |
| ▸ | F11 | P03951 | 5/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23088171 | 1.00 | NOTUM (0.39) | NOTUMALDH1A1TSHRKMT2AKLKB1 | |
| SCHEMBL23088269 | 0.88 | ALDH1A1 (0.40) | NOTUMALDH1A1TSHRKMT2AKLKB1 | |
| SCHEMBL29792712 | 0.88 | ALDH1A1 (0.40) | NOTUMALDH1A1TSHRKMT2AKLKB1 | |
| SCHEMBL29792627 | 0.87 | NOTUM (0.42) | NOTUMALDH1A1TSHRKMT2AKLKB1 | |
| SCHEMBL23088016 | 0.87 | NOTUM (0.42) | NOTUMALDH1A1TSHRKMT2AKLKB1 | |
| SCHEMBL17221253 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TSHRKMT2AKLKB1F11 | |
| SCHEMBL29407413 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TSHRKMT2AKLKB1F11 | |
| SCHEMBL23088005 | 0.77 | NOTUM (0.50) | NOTUMALDH1A1KMT2AKLKB1F11 | |
| SCHEMBL23088411 | 0.77 | ALDH1A1 (0.39) | NOTUMALDH1A1TSHRKMT2ANPSR1 | |
| SCHEMBL23088152 | 0.75 | ALDH1A1 (0.40) | NOTUMALDH1A1TSHRKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031547-A1 | PLASMA KALLIKREIN INHIBITORS AND USES THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2022-07-27 | — | — | EP | disclosed |