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SCHEMBL29792804

SCHEMBL29792804

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)[C@H](OC)[C@@H]2O[Si](C)(C)C(C)(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 6/20 0.50
▸ PRMT6 Q96LA8 1/20 0.44
▸ ADORA1 P30542 3/20 0.42
▸ P2RY12 Q9H244 1/20 0.41
▸ ADORA2A P29274 1/20 0.41
▸ ADORA2B P29275 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8380846 0.97 TYMP (0.51) TYMPPRMT6ADORA1P2RY12ADORA2A
SCHEMBL20482910 0.93 TYMP (0.55) TYMPADORA1P2RY12ADORA2AADORA2B
SCHEMBL21591934 0.93 TYMP (0.55) TYMPADORA1P2RY12ADORA2AADORA2B
SCHEMBL8385935 0.93 TYMP (0.55) TYMPADORA1P2RY12ADORA2AADORA2B
SCHEMBL8385934 0.93 TYMP (0.55) TYMPADORA1P2RY12ADORA2AADORA2B
SCHEMBL29814199 0.93 TYMP (0.55) TYMPADORA1P2RY12ADORA2AADORA2B
SCHEMBL19493438 0.93 TYMP (0.55) TYMPPRMT6ADORA1P2RY12ADORA2A
SCHEMBL21305068 0.93 TYMP (0.55) TYMPPRMT6ADORA1P2RY12ADORA2A
SCHEMBL6396836 0.93 TYMP (0.55) TYMPPRMT6ADORA1P2RY12ADORA2A
SCHEMBL8381924 0.93 TYMP (0.55) TYMPPRMT6ADORA1P2RY12ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4277636-A1 MODIFIED OLIGONUCLEOTIDES Alnylam Pharmaceuticals, Inc. (US) 2023-11-22 — — EP disclosed
WO-2022155418-A1 MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2022-07-21 — — WO disclosed