SCHEMBL29792990

SCHEMBL29792990

CC(C)[Si]1(C(C)C)OC[C@H]2O[C@@H](n3cnc4c(Cl)ncnc43)C(O)C2O[Si](C(C)C)(C(C)C)O1

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PDE4A P27815 7/20 0.56
▸ PDE4B Q07343 7/20 0.56
▸ PDE4C Q08493 7/20 0.56
▸ PDE4D Q08499 7/20 0.56
▸ STING1 Q86WV6 4/20 0.44
▸ LMNA P02545 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ RAPGEF3 O95398 2/20 0.43
▸ GMNN O75496 1/20 0.43
▸ BLM P54132 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ RAPGEF4 Q8WZA2 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ RXFP1 Q9HBX9 2/20 0.42
▸ TYMP P19971 1/20 0.40
▸ AHCY P23526 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16871701 1.00 PDE4A (0.56) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL17889822 1.00 PDE4A (0.56) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL1801703 1.00 PDE4A (0.56) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL17612283 0.90 STING1 (0.45) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL22983991 0.89 STING1 (0.56) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL9964279 0.89 STING1 (0.56) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL6895355 0.89 STING1 (0.56) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL14946346 0.89 STING1 (0.56) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL23813544 0.89 STING1 (0.56) PDE4APDE4BPDE4CPDE4DSTING1
SCHEMBL16271105 0.89 STING1 (0.56) PDE4APDE4BPDE4CPDE4DSTING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4277636-A1 MODIFIED OLIGONUCLEOTIDES Alnylam Pharmaceuticals, Inc. (US) 2023-11-22 — — EP disclosed
WO-2022155418-A1 MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2022-07-21 — — WO disclosed
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