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SCHEMBL29793002

SCHEMBL29793002

COc1ccc(C(OC[C@]23COC(C2OP(OCCC#N)N(C(C)C)C(C)C)[C@H](n2cnc4c(N(C)C(=O)c5ccccc5)ncnc42)O3)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 1/20 0.33
▸ LMNA P02545 2/20 0.30
▸ SMN1; SMN2 Q16637 2/20 0.30
▸ ANPEP P15144 1/20 0.30
▸ NPEPPS P55786 1/20 0.30
▸ TP53 P04637 1/20 0.30
▸ CYP3A4 P08684 1/20 0.30
▸ HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29793195 0.95 TYMP (0.33) TYMPLMNA
SCHEMBL27193637 0.91 TYMP (0.31) TYMP
SCHEMBL29881527 0.91 TYMP (0.34) TYMP
SCHEMBL1096766 0.91 TYMP (0.34) TYMP
SCHEMBL5558224 0.91 TYMP (0.34) TYMP
SCHEMBL25727 0.85 TYMP (0.33) TYMP
SCHEMBL4620914 0.85 CDK5 (0.34) TYMP
SCHEMBL31196681 0.83 KDM4E (0.36) TYMP
SCHEMBL29792957 0.83 TYMP (0.42) TYMPLMNASMN1; SMN2ANPEPNPEPPS
SCHEMBL30141086 0.83 TYMP (0.33) TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4277636-A1 MODIFIED OLIGONUCLEOTIDES Alnylam Pharmaceuticals, Inc. (US) 2023-11-22 — — EP disclosed
WO-2022155418-A9 MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2023-03-09 — — WO disclosed
WO-2022155418-A1 MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2022-07-21 — — WO disclosed