SCHEMBL25727

SCHEMBL25727

COc1ccc(C(OC[C@@]23CCO[C@@H]([C@H](n4cnc5c(NC(=O)c6ccccc6)ncnc54)O2)[C@@H]3OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.33
PRMT6 Q96LA8 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA2B P29275 1/20 0.32
GAPDH P04406 1/20 0.32
PRKAG1 P54619 1/20 0.31
PRKAA1 Q13131 1/20 0.31
PRKAB1 Q9Y478 1/20 0.31
P2RY12 Q9H244 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29881527 0.95 TYMP (0.34) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL5558224 0.95 TYMP (0.34) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL1096766 0.95 TYMP (0.34) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL23827254 0.88 TYMP (0.33) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL30898734 0.88 TYMP (0.33) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL1667985 0.88 TYMP (0.34) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL1665982 0.88 TYMP (0.34) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL20394008 0.88 TYMP (0.32) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL23827276 0.88 TYMP (0.33) TYMPPRMT6ADORA2AADORA2BGAPDH
SCHEMBL4620914 0.88 CDK5 (0.34) TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1152009-B2 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES DAIICHI SANKYO CO LTD (JP) 2017-09-06 EP claimed
EP-1152009-B1 NOVEL NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGUES SANKYO CO (JP) 2005-01-26 EP claimed
US-20230348522-A1 METHOD FOR PRODUCING BICYCLIC PHOSPHORAMIDITE DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-11-02 US disclosed
US-9885036-B2 Double-stranded polynucleotide DAIICHI SANKYO COMPANY, LIMITED (JP) 2018-02-06 US disclosed
US-9657049-B2 ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors Matsuo, Masafumi (JP) 2017-05-23 US disclosed
US-9657050-B2 ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors Masafumi, Matsuo (JP) 2017-05-23 US disclosed
EP-2530153-B1 ENA nucleic acid drugs modifying splicing in mRNA precursor MATSUO MASAFUMI (JP) 2016-03-16 EP disclosed
EP-2530155-B1 ENA nucleic acid drugs modifying splicing in mRNA precursor MATSUO MASAFUMI (JP) 2016-03-16 EP disclosed
EP-2530154-B1 ENA nucleic acid drugs modifying splicing in mRNA precursor MATSUO MASAFUMI (JP) 2016-03-16 EP disclosed
US-9243026-B2 ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-26 US disclosed
US-20160002636-A1 ENA NUCLEIC ACID PHARMACEUTICALS CAPABLE OF MODIFYING SPLICING OF mRNA PRECURSORS DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-07 US disclosed
EP-2374885-A2 ENA nucleic acid drugs modifying splicing in mRNA precursor Matsuo, Masafumi (JP) 2011-10-12 EP disclosed
US-20110152353-A1 DOUBLE-STRANDED POLYNUCLEOTIDE DAIICHI SANKYO COMPANY, LIMITED 2011-06-23 US disclosed
US-7902160-B2 ENA nucleic acid drugs modifying splicing in mRNA precursor Matsuo, Masafumi (JP) 2011-03-08 US disclosed
US-20110046360-A1 ENA NUCLEIC ACID DRUGS MODIFYING SPLICING IN mRNA PRECURSOR Matsuo, Masafumi (JP) 2011-02-24 US disclosed
EP-2135948-A2 ENA nucleic acid drugs modifying splicing in mRNA precursor Matsuo, Masafumi (JP) 2009-12-23 EP disclosed
US-20070117773-A1 Telomerase-inhibiting ENA oligonucleotide SANKYO COMPANY, LIMITED (JP) 2007-05-24 US disclosed
EP-1783216-A1 TELOMERASE-INHIBITORY ENA OLIGONUCLEOTIDE Sankyo Company, Limited (JP) 2007-05-09 EP disclosed
US-20070082861-A1 Ena nucleic acid drugs modifying splicing in mrna precursor MASAFUMI MATSUO (JP) 2007-04-12 US disclosed
EP-1568769-A1 ENA NUCLEIC ACID DRUGS MODIFYING SPLICING IN mRNA PRECURSOR Matsuo, Masafumi (JP) 2005-08-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152353-A1 DOUBLE-STRANDED POLYNUCLEOTIDE NSUN2, TRDMT1, POLRMT TYMP 151/4885PRMT6 574/4885ADORA2A 1521/4885
US-20070117773-A1 Telomerase-inhibiting ENA oligonucleotide TERT, ENO1, TERB1 TYMP 59/4885PRMT6 2148/4885ADORA2A 912/4885
US-20110046360-A1 ENA NUCLEIC ACID DRUGS MODIFYING SPLICING IN mRNA PRECURSOR SNRPA, RBM17, SNRPA1 TYMP 526/4885PRMT6 1467/4885ADORA2A 577/4885
US-20230348522-A1 METHOD FOR PRODUCING BICYCLIC PHOSPHORAMIDITE PFAS, ENPP1, NAAA TYMP 113/4885PRMT6 2053/4885ADORA2A 2111/4885
US-20070082861-A1 Ena nucleic acid drugs modifying splicing in mrna precursor SNRPA, RBM17, SNRPA1 TYMP 526/4885PRMT6 1467/4885ADORA2A 577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.