Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 9/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978657 | 0.88 | LDLR (0.74) | LDLRMAPK14KITMAPK11LCK | |
| SCHEMBL2966826 | 0.83 | LDLR (1.00) | LDLRMAPK14KITMAPK11LCK | |
| SCHEMBL7855514 | 0.77 | LDLR (0.60) | LDLRMAPK14KITMAPK11LCK | |
| SCHEMBL13234997 | 0.76 | LDLR (0.67) | LDLRMAPK14KITLCKSRC | |
| SCHEMBL2951658 | 0.75 | LDLR (0.66) | LDLRMAPK14KITMAPK11LCK | |
| SCHEMBL4248774 | 0.73 | MEN1 (0.53) | LDLRKMT2ATP53 | |
| SCHEMBL2969095 | 0.72 | LDLR (0.52) | LDLRMAPK14 | |
| SCHEMBL2943393 | 0.72 | MAPK14 (0.60) | LDLRALDH1A1MAPK14KITLCK | |
| SCHEMBL6782262 | 0.72 | LDLR (0.74) | LDLRALDH1A1KDM4EMAPK14KMT2A | |
| SCHEMBL2949693 | 0.72 | MAPK14 (0.62) | LDLRALDH1A1MAPK14KITLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772432-B2 | Amidobenzamide derivatives which are useful as cytokine inhibitors | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| US-20050038081-A1 | Amidobenzamide derivatives which are useful as cytokine inhibitors | ASTRAZENECA | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038081-A1 | Amidobenzamide derivatives which are useful as cytokine inhibitors | IL6, IL6ST, IL2 | LDLR 3410/4885ALDH1A1 293/4885KDM4E 1072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.