Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 1.00 |
| ▸ | GAA | P10253 | 10/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 8/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.80 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 8/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.65 |
| ▸ | GFER | P55789 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28473939 | 1.00 | MAPT (1.00) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL28475909 | 0.86 | MAPT (0.84) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL29793935 | 0.84 | KMT2A (0.73) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL28900952 | 0.84 | KMT2A (0.73) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL28956688 | 0.80 | KMT2A (0.80) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL28484863 | 0.80 | KMT2A (0.73) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL28863297 | 0.79 | KMT2A (1.00) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL28478378 | 0.78 | GAA (1.00) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL23657826 | 0.74 | KMT2A (0.76) | MAPTGAAKMT2AMEN1KDM4E | |
| SCHEMBL29793950 | 0.73 | KMT2A (0.72) | MAPTGAAKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111909082-B | Pyridine hydrazone derivatives, and preparation method and application thereof | 湖南大学 | 2022-09-13 | — | — | CN | disclosed |