Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.32 |
| ▸ | CASP1 | P29466 | 6/20 | 0.32 |
| ▸ | CASP7 | P55210 | 6/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 5/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.32 |
| ▸ | USP2 | O75604 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18150906 | 1.00 | MAPT (0.35) | MAPTBMPR1AACVR1BACVRL1ACVR1 | |
| SCHEMBL18151303 | 0.93 | PDE10A (0.34) | MAPTBMPR1AACVR1BACVRL1ACVR1 | |
| SCHEMBL29795054 | 0.93 | PDE10A (0.34) | MAPTBMPR1AACVR1BACVRL1ACVR1 | |
| SCHEMBL29795015 | 0.91 | PIK3CA (0.35) | MAPTTNFALDH1A1CYP1A2CASP1 | |
| SCHEMBL18151455 | 0.91 | PIK3CA (0.35) | MAPTTNFALDH1A1CYP1A2CASP1 | |
| SCHEMBL18151674 | 0.90 | TNF (0.35) | MAPTPDE10ATNFALDH1A1CYP1A2 | |
| SCHEMBL29794932 | 0.90 | TNF (0.35) | MAPTPDE10ATNFALDH1A1CYP1A2 | |
| SCHEMBL18151452 | 0.90 | PDE10A (0.33) | MAPTBMPR1AACVR1BACVRL1ACVR1 | |
| SCHEMBL29794859 | 0.90 | PDE10A (0.33) | MAPTBMPR1AACVR1BACVRL1ACVR1 | |
| SCHEMBL18150619 | 0.88 | TNF (0.36) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4493221-A2 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2025-01-22 | — | — | EP | disclosed |
| CN-119212727-A | Targeted bifunctional degradants | 耶鲁大学 | 2024-12-27 | — | — | CN | disclosed |
| WO-2024182772-A2 | MANNOSE 6-PHOSPHATE RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2024-09-06 | — | — | WO | disclosed |
| WO-2023178199-A2 | TARGETED BIFUNCTIONAL DEGRADERS | YALE UNIVERSITY (US) | 2023-09-21 | — | — | WO | disclosed |
| EP-4041262-A1 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2022-08-17 | — | — | EP | disclosed |