Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18151452 | 1.00 | PDE10A (0.33) | PDE10AMAPTCHRNB2CHRNA4ROCK2 | |
| SCHEMBL29795054 | 0.97 | PDE10A (0.34) | PDE10AMAPTBMPR1AACVR1BACVRL1 | |
| SCHEMBL18151303 | 0.97 | PDE10A (0.34) | PDE10AMAPTBMPR1AACVR1BACVRL1 | |
| SCHEMBL18151140 | 0.90 | PIK3CA (0.34) | PDE10AMAPTTNF | |
| SCHEMBL29794880 | 0.90 | MAPT (0.35) | PDE10AMAPTBMPR1AACVR1BACVRL1 | |
| SCHEMBL18150906 | 0.90 | MAPT (0.35) | PDE10AMAPTBMPR1AACVR1BACVRL1 | |
| SCHEMBL29794921 | 0.88 | PDE10A (0.34) | PDE10AMAPTTNF | |
| SCHEMBL18151613 | 0.88 | PDE10A (0.34) | PDE10AMAPTTNF | |
| SCHEMBL18151337 | 0.86 | TNF (0.35) | TNF | |
| SCHEMBL29794897 | 0.86 | TNF (0.35) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4493221-A2 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2025-01-22 | — | — | EP | disclosed |
| WO-2024182772-A2 | MANNOSE 6-PHOSPHATE RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2024-09-06 | — | — | WO | disclosed |
| WO-2023178199-A2 | TARGETED BIFUNCTIONAL DEGRADERS | YALE UNIVERSITY (US) | 2023-09-21 | — | — | WO | disclosed |
| EP-4041262-A1 | TARGETED BIFUNCTIONAL DEGRADERS | Yale University (US) | 2022-08-17 | — | — | EP | disclosed |