Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 4/20 | 0.56 |
| ▸ | PAK4 | O96013 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24645842 | 1.00 | PDE2A (0.57) | PDE2APLK4PAK4ALDH1A1POLB | |
| SCHEMBL17443015 | 0.83 | APP (0.62) | PLK4PAK4ALDH1A1PDE5ALMNA | |
| SCHEMBL17933800 | 0.77 | SGK1 (0.51) | PDE2APLK4PAK4PDE5ALMNA | |
| SCHEMBL17009449 | 0.76 | POLB (0.65) | ALDH1A1POLBPDE5AHSD17B10LMNA | |
| SCHEMBL30861057 | 0.75 | PLK4 (0.54) | PDE2APLK4PAK4ALDH1A1LMNA | |
| SCHEMBL27227932 | 0.75 | PLK4 (0.54) | PDE2APLK4PAK4ALDH1A1LMNA | |
| SCHEMBL22904675 | 0.73 | PDE2A (0.60) | PDE2APLK4PAK4PDE5ALMNA | |
| SCHEMBL17933806 | 0.73 | PLK4 (0.41) | PDE2APLK4PAK4ALDH1A1POLB | |
| SCHEMBL20209844 | 0.73 | PLK4 (0.57) | PDE2APLK4PAK4POLBPDE5A | |
| SCHEMBL13896217 | 0.73 | MAPK1 (0.59) | PDE2APLK4PAK4HTTCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259253-A1 | CD73 INHIBITORS | ORIC PHARMACEUTICALS, INC. | 2022-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259253-A1 | CD73 INHIBITORS | ENTPD5, NT5E, ENTPD1 | PDE2A 224/4885PLK4 3744/4885PAK4 2202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.