Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 3/20 | 0.57 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17443015 | 0.83 | APP (0.62) | PLK4CCNE1CDK2APPKMT2A | |
| SCHEMBL17933800 | 0.82 | SGK1 (0.51) | PLK4APPPAK4ROCK2PDE2A | |
| SCHEMBL21332784 | 0.81 | CCNE2 (0.51) | PLK4CCNE2CCNE1CDK2APP | |
| SCHEMBL24087494 | 0.81 | MAP2K4 (0.53) | PLK4CCNE2CCNE1CDK2APP | |
| SCHEMBL22904675 | 0.80 | PDE2A (0.60) | PLK4APPPAK4PDE2ALMNA | |
| Hydrochloric Acid SCHEMBL8888083 | 0.79 | LMNA (0.67) | PLK4POLBMEN1KMT2AMAPT | |
| SCHEMBL15619030 | 0.78 | CCNE2 (0.68) | CCNE2CCNE1CDK2APPPOLB | |
| SCHEMBL25881948 | 0.78 | CNR2 (0.47) | PLK4APPPOLBMAPTHTT | |
| SCHEMBL3108883 | 0.77 | MEN1 (0.60) | CCNE2CCNE1CDK2APPPOLB | |
| SCHEMBL1685041 | 0.77 | APP (0.74) | APPPOLBCLK4LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114667282-B | Pyrimidine amide compounds and methods of treating cancer | 昊运股份有限公司 | 2024-09-03 | — | — | CN | disclosed |
| US-20240150356-A1 | Pyrimidine amide compounds and use thereof | ALPHALA CO., LTD. (TW) | 2024-05-09 | — | — | US | disclosed |
| WO-2023244430-A1 | PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF | ALPHALA CO., LTD. (TW) | 2023-12-21 | — | — | WO | disclosed |
| EP-4048656-A1 | PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF | Alphala Co., Ltd. (TW) | 2022-08-31 | — | — | EP | disclosed |
| CN-111819178-B | Crystal form of pyrazolo heteroaryl derivative hydrochloride and preparation method thereof | 江苏恒瑞医药股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| US-20210380593-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2021-12-09 | — | — | US | disclosed |
| US-11117898-B2 | Pyrazolo-heteroaryl derivative, preparation method and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-09-14 | — | — | US | disclosed |
| EP-3546457-B1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2021-07-14 | — | — | EP | disclosed |
| US-20210188856-A1 | CRYSTAL FORM OF HYDROCHLORIDE OF PYRAZOLOHETEROARYL DERIVATIVE AND PREPARATION METHOD | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD (CN) | 2021-06-24 | — | — | US | disclosed |
| WO-2021080980-A1 | PYRIMIDINE AMIDE COMPOUNDS AND USE THEREOF | ALPHALA CO., LTD. (TW) | 2021-04-29 | — | — | WO | disclosed |
| US-20210115046-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-04-22 | — | — | US | disclosed |
| EP-3808745-A1 | CRYSTAL FORM OF HYDROCHLORIDE OF PYRAZOLOHETEROARYL DERIVATIVE AND PREPARATION METHOD | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2021-04-21 | — | — | EP | disclosed |
| EP-3546457-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018095426-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115046-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | TLR7, TLR3, TLR4 | PLK4 2658/4885CCNE2 4527/4885CCNE1 4666/4885 |
| US-11117898-B2 | Pyrazolo-heteroaryl derivative, preparation method and medical use thereof | TLR7, TLR3, TLR4 | PLK4 2658/4885CCNE2 4527/4885CCNE1 4666/4885 |
| US-20240150356-A1 | Pyrimidine amide compounds and use thereof | TYMP, DPYD, TYMS | PLK4 1513/4885CCNE2 706/4885CCNE1 144/4885 |
| US-20210188856-A1 | CRYSTAL FORM OF HYDROCHLORIDE OF PYRAZOLOHETEROARYL DERIVATIVE AND PREPARATION METHOD | CYP2F1, CYP7A1, CYP11B2 | PLK4 1252/4885CCNE2 2852/4885CCNE1 3463/4885 |
| US-20210380593-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | TLR7, TLR3, TLR4 | PLK4 2658/4885CCNE2 4527/4885CCNE1 4666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.