Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619935 | 0.86 | ASAH1 (0.64) | ASAH1SMN1; SMN2APAF1NPC1ALDH1A1 | |
| SCHEMBL28794811 | 0.84 | ASAH1 (0.64) | ASAH1SMN1; SMN2APAF1NPC1ALDH1A1 | |
| SCHEMBL29795462 | 0.84 | ASAH1 (0.64) | ASAH1SMN1; SMN2APAF1NPC1ALDH1A1 | |
| SCHEMBL10654951 | 0.82 | ASAH1 (0.90) | ASAH1SMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL29795663 | 0.81 | ASAH1 (0.97) | ASAH1NPC1ALDH1A1MAPTHPGD | |
| SCHEMBL23122842 | 0.80 | ASAH1 (0.83) | ASAH1SMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL29795449 | 0.80 | ASAH1 (0.83) | ASAH1SMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL29795432 | 0.79 | ASAH1 (0.43) | ASAH1SMN1; SMN2NPC1HPGDNAMPT | |
| SCHEMBL13897309 | 0.78 | ASAH1 (0.70) | ASAH1SMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL28794776 | 0.78 | ASAH1 (0.77) | ASAH1SMN1; SMN2NPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031532-A1 | SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | Bial-R&D Investments, S.A. (PT) | 2022-07-27 | — | — | EP | disclosed |