Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389880 | 1.00 | TGFBR1 (0.38) | TGFBR1KDRATRFGFR1FGFR2 | |
| SCHEMBL23418878 | 0.88 | KDR (0.43) | TGFBR1KDRATRFGFR1FGFR2 | |
| SCHEMBL29796700 | 0.87 | TGFBR1 (0.39) | TGFBR1KDRATRFGFR1FGFR2 | |
| SCHEMBL23389890 | 0.87 | TGFBR1 (0.39) | TGFBR1KDRATRFGFR1FGFR2 | |
| SCHEMBL23389975 | 0.85 | ABL1 (0.40) | TGFBR1KDRATRFGFR1FGFR2 | |
| SCHEMBL28785431 | 0.83 | TGFBR1 (0.41) | TGFBR1KDRATRFGFR1FGFR2 | |
| SCHEMBL30156362 | 0.83 | TGFBR1 (0.38) | TGFBR1KDRATRFGFR1FGFR2 | |
| SCHEMBL25084993 | 0.83 | TGFBR1 (0.38) | TGFBR1KDRATRFGFR1FGFR2 | |
| SCHEMBL22075188 | 0.83 | BRAF (0.40) | KDRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22102693 | 0.82 | BRAF (0.37) | KDRFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061809-A1 | SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-09-28 | — | — | EP | disclosed |
| CN-114728941-A | Substituted 1, 5-naphthyridines or quinolines as ALK5 inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-08 | — | — | CN | disclosed |