Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23392193 | 1.00 | TGFBR1 (0.40) | TGFBR1MAPK14METAP2MTORCCR1 | |
| SCHEMBL23389969 | 0.86 | TGFBR1 (0.38) | TGFBR1MAPK14METAP2MTOR | |
| SCHEMBL29796618 | 0.86 | TGFBR1 (0.38) | TGFBR1MAPK14METAP2MTOR | |
| SCHEMBL23408090 | 0.83 | TGFBR1 (0.42) | TGFBR1MAPK14MTOR | |
| SCHEMBL23389852 | 0.81 | LRRK2 (0.39) | TGFBR1MAPK14 | |
| SCHEMBL29796486 | 0.80 | TGFBR1 (0.42) | TGFBR1MAPK14METAP2MTORCCR1 | |
| SCHEMBL29796586 | 0.80 | TGFBR1 (0.45) | TGFBR1MAPK14MTOR | |
| SCHEMBL23390013 | 0.80 | TGFBR1 (0.42) | TGFBR1MAPK14METAP2MTORCCR1 | |
| SCHEMBL23389848 | 0.80 | TGFBR1 (0.45) | TGFBR1MAPK14MTOR | |
| SCHEMBL28785430 | 0.79 | TGFBR1 (0.41) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728941-A | Substituted 1, 5-naphthyridines or quinolines as ALK5 inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-08 | — | — | CN | disclosed |