Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 4/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.39 |
| ▸ | CLK3 | P49761 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 5/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389913 | 1.00 | PDGFRB (0.45) | PDGFRBPDGFRACYP2A6TGFBR1FGFR1 | |
| SCHEMBL25084603 | 0.84 | PDGFRB (0.47) | PDGFRBPDGFRACYP2A6TGFBR1FGFR1 | |
| SCHEMBL30156319 | 0.84 | PDGFRB (0.47) | PDGFRBPDGFRACYP2A6TGFBR1FGFR1 | |
| SCHEMBL29796620 | 0.82 | TGFBR1 (0.40) | TGFBR1MAPK14 | |
| SCHEMBL23407940 | 0.82 | TGFBR1 (0.38) | TGFBR1MAPK14 | |
| SCHEMBL29796618 | 0.82 | TGFBR1 (0.38) | TGFBR1GRM5MAPK14 | |
| SCHEMBL23389969 | 0.82 | TGFBR1 (0.38) | TGFBR1GRM5MAPK14 | |
| SCHEMBL23390032 | 0.82 | TGFBR1 (0.40) | TGFBR1MAPK14 | |
| SCHEMBL25084880 | 0.82 | CYP2A6 (0.46) | PDGFRBPDGFRACYP2A6TGFBR1FGFR1 | |
| SCHEMBL30156631 | 0.82 | CYP2A6 (0.46) | PDGFRBPDGFRACYP2A6TGFBR1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061809-A1 | SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-09-28 | — | — | EP | disclosed |
| CN-114728941-A | Substituted 1, 5-naphthyridines or quinolines as ALK5 inhibitors | 施万生物制药研发IP有限责任公司 | 2022-07-08 | — | — | CN | disclosed |