Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26961690 | 1.00 | GAA (0.36) | GAAPLATBTKEPHX2 | |
| SCHEMBL31375493 | 0.93 | GAA (0.34) | GAA | |
| SCHEMBL26962195 | 0.93 | GAA (0.35) | GAA | |
| SCHEMBL30830363 | 0.91 | GAA (0.34) | GAA | |
| SCHEMBL29796818 | 0.91 | GAA (0.32) | GAA | |
| SCHEMBL26961708 | 0.91 | GAA (0.32) | GAA | |
| SCHEMBL26962347 | 0.85 | GAA (0.37) | GAABTKEPHX2 | |
| SCHEMBL29797169 | 0.85 | GAA (0.37) | GAABTKEPHX2 | |
| SCHEMBL31628392 | 0.84 | HDAC6 (0.40) | GAAPLATBTK | |
| SCHEMBL31375533 | 0.84 | HDAC6 (0.40) | GAAPLATBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568959-A1 | BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | disclosed |
| EP-4291558-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022171745-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2022-08-18 | — | — | WO | disclosed |