SCHEMBL29797263

SCHEMBL29797263

COc1ccc(C(CC(=O)OC(C)(C)C)c2cc(CCCC(C)=O)n(COCC[Si](C)(C)C)n2)cc1F

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 2/20 0.33
ITGAV P06756 2/20 0.33
ITGA2B P08514 1/20 0.33
ITGB6 P18564 1/20 0.33
FFAR1 O14842 1/20 0.31
MTNR1A P48039 1/20 0.30
MTNR1B P49286 1/20 0.30
PDE4D Q08499 1/20 0.30
GCGR P47871 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20139568 1.00 ITGB3 (0.33) ITGB3ITGAVITGA2BITGB6FFAR1
SCHEMBL20141586 0.91 FFAR1 (0.37) ITGB3ITGAVITGA2BITGB6FFAR1
SCHEMBL20141540 0.89 FFAR1 (0.34) ITGB3ITGAVITGA2BITGB6FFAR1
SCHEMBL29797568 0.89 FFAR1 (0.34) ITGB3ITGAVITGA2BITGB6FFAR1
SCHEMBL29797313 0.89 ITGB3 (0.33) ITGB3ITGAVITGA2BITGB6
SCHEMBL20140343 0.89 ITGB3 (0.33) ITGB3ITGAVITGA2BITGB6
SCHEMBL29797157 0.87 ITGB3 (0.36) ITGB3ITGAVITGA2BITGB6
SCHEMBL20140611 0.87 ITGB3 (0.36) ITGB3ITGAVITGA2BITGB6
SCHEMBL21311561 0.85 FFAR1 (0.34) ITGB3ITGAVITGA2BITGB6FFAR1
SCHEMBL29797306 0.85 ITGAV (0.54) ITGB3ITGAVITGA2BITGB6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110167935-B 3-substituted propionic acids as alpha V integrin inhibitors 百时美施贵宝公司 2022-05-27 CN disclosed