Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.62 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.62 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29798204 | 0.85 | TSHR (0.61) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL21952032 | 0.85 | TSHR (0.63) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL29798080 | 0.83 | CYP11B2 (0.58) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL29798026 | 0.83 | TSHR (0.61) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL29798346 | 0.78 | MAPT (0.50) | TSHRALDH1A1LMNAMAPK1NPC1 | |
| SCHEMBL28669428 | 0.76 | TSHR (0.63) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL29798040 | 0.75 | MAPK1 (0.45) | TSHRAPOBEC3AAPOBEC3GALDH1A1MAPK1 | |
| SCHEMBL22009411 | 0.75 | TSHR (0.86) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL21952015 | 0.75 | TSHR (0.70) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA | |
| SCHEMBL30278759 | 0.75 | TSHR (0.70) | TSHRAPOBEC3AAPOBEC3GALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149461-A1 | UBIQUITIN-LIGASE INHIBITORS FOR THE TREATMENT OF CANCER | Fundación Profesor Novoa Santos (ES) | 2023-03-22 | — | — | EP | disclosed |
| WO-2021229035-A9 | UBIQUITIN-LIGASE INHIBITORS FOR THE TREATMENT OF CANCER | FUNDACIÓN PROFESOR NOVOA SANTOS (ES) | 2022-09-09 | — | — | WO | disclosed |