Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2972629 | 0.90 | MAPT (0.54) | MAPTKCNN4CA12CA1CA7 | |
| SCHEMBL5926048 | 0.86 | NPC1 (0.46) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL28318676 | 0.86 | KCNN4 (0.46) | MAPTKCNN4CA12CA1CA7 | |
| SCHEMBL3375626 | 0.82 | MAPT (0.42) | MAPTCA12CA1CA7CA14 | |
| SCHEMBL6473387 | 0.81 | MAPT (0.45) | MAPTCA12CA1CA7CA14 | |
| SCHEMBL8219589 | 0.81 | MAPT (0.45) | MAPTCA12CA1CA7CA14 | |
| SCHEMBL28280071 | 0.78 | KCNN4 (0.53) | MAPTKCNN4CYP2C19HIF1AKMT2A | |
| SCHEMBL7849694 | 0.77 | MAPT (0.39) | MAPTCA12CA1CA7CA14 | |
| SCHEMBL7319974 | 0.77 | CA12 (0.43) | CA12CA1CA7CA14ATM | |
| SCHEMBL27158981 | 0.77 | CA12 (0.43) | CA12CA1CA7CA14ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786163-B2 | Constrained cyano compounds | Forest Laboratories Holdings Limited (BM) | 2010-08-31 | — | — | US | disclosed |
| US-7786163-B2 | Constrained cyano compounds | Forest Laboratories Holdings Limited (BM) | 2010-08-31 | — | — | US | disclosed |
| US-7786163-B2 | Constrained cyano compounds | Forest Laboratories Holdings Limited (BM) | 2010-08-31 | — | — | US | disclosed |
| EP-1778220-A1 | CONSTRAINED CYANO COMPOUNDS | Phenomix Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006017292-A1 | CONSTRAINED CYANO COMPOUNDS | PHENOMIX CORPORATION (US) | 2006-02-16 | — | — | WO | disclosed |
| US-20060009518-A1 | Constrained cyano compounds | Forest Laboratories Holding Limited (BM) | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009518-A1 | Constrained cyano compounds | DNPEP, PREP, PEPD | MAPT 4255/4885KCNN4 4368/4885CA12 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.