Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2700 | 0.93 | AGTR1 (0.47) | AGTR1MMEFFAR1AKR1B1LTB4R2 | |
| SCHEMBL2034 | 0.93 | AGTR1 (0.47) | AGTR1MMEFFAR1AKR1B1LTB4R2 | |
| SCHEMBL10050910 | 0.91 | MME (0.41) | AGTR1MMEFFAR1AKR1B1OXTR | |
| SCHEMBL2630 | 0.89 | AGTR1 (0.40) | AGTR1MMEFFAR1AKR1B1LTB4R2 | |
| SCHEMBL2918 | 0.89 | AGTR1 (0.40) | AGTR1MMEFFAR1AKR1B1LTB4R2 | |
| SCHEMBL2979 | 0.84 | AGTR1 (0.57) | AGTR1MMEFFAR1AKR1B1LTB4R2 | |
| SCHEMBL2978 | 0.84 | AGTR1 (0.57) | AGTR1MMEFFAR1AKR1B1LTB4R2 | |
| SCHEMBL2443439 | 0.84 | LTB4R2 (0.44) | AGTR1MMEFFAR1AKR1B1LTB4R2 | |
| SCHEMBL2141 | 0.83 | FFAR1 (0.43) | AGTR1MMEFFAR1AKR1B1LTB4R2 | |
| SCHEMBL14998792 | 0.82 | AGTR1 (0.44) | AGTR1MMEFFAR1AKR1B1OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |