Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sodelglitazar. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD known ✓ | Q03181 | 19/20 | 0.59 |
| ▸ | PPARA known ✓ | Q07869 | 17/20 | 0.59 |
| ▸ | PPARG known ✓ | P37231 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sodelglitazar SCHEMBL4822839 | 1.00 | PPARD (0.59) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| Sodelglitazar SCHEMBL29378834 | 1.00 | PPARD (0.59) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6838544 | 0.91 | PPARD (0.55) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6236397 | 0.87 | PPARD (0.78) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6385692 | 0.83 | PPARD (0.53) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4812687 | 0.80 | PPARD (0.69) | PPARDPPARAPPARG | |
| SCHEMBL4808599 | 0.78 | PPARD (0.66) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4827386 | 0.78 | PPARD (0.49) | PPARDPPARAPPARG | |
| SCHEMBL4806719 | 0.78 | PPARD (0.65) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL12267474 | 0.78 | PPARA (0.49) | PPARDPPARAPPARGMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031124-A1 | USE OF A PPAR-DELTA AGONIST IN THE TREATMENT OF KIDNEY DISEASE | Reneo Pharmaceuticals, Inc. (US) | 2022-07-27 | — | — | EP | claimed |
| EP-4031124-A1 | USE OF A PPAR-DELTA AGONIST IN THE TREATMENT OF KIDNEY DISEASE | Reneo Pharmaceuticals, Inc. (US) | 2022-07-27 | — | — | EP | disclosed |