Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 20/20 | 0.53 |
| ▸ | PPARA | Q07869 | 14/20 | 0.53 |
| ▸ | PPARG | P37231 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166922 | 0.85 | PPARD (0.69) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6236397 | 0.84 | PPARD (0.78) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| Sodelglitazar SCHEMBL29801577 | 0.83 | PPARD (0.59) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| Sodelglitazar SCHEMBL4822839 | 0.83 | PPARD (0.59) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| Sodelglitazar SCHEMBL29378834 | 0.83 | PPARD (0.59) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL2166925 | 0.82 | PPARD (0.50) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6838544 | 0.81 | PPARD (0.55) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL16147339 | 0.80 | PPARD (0.71) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL6388947 | 0.78 | MPL (0.43) | PPARDPPARAPPARGALDH1A1MAPT | |
| SCHEMBL6758620 | 0.77 | PPARD (0.58) | PPARDPPARAPPARGMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439259-B2 | Thiazole derivatives for treating PPAR related disorders | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439259-B2 | Thiazole derivatives for treating PPAR related disorders | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-21 | — | — | US | disclosed |
| US-20050159598-A1 | Process for preparation of chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2005-07-21 | — | — | US | disclosed |
| EP-1478630-A2 | PROCESS AND INTERMEDIATES FOR PREPARING PHENYLTHIOMETHYL-THIAZOLES OR -OXAZOLES | SmithKline Beecham Corporation (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003074504-A2 | PROCESS AND INTERMEDIATES FOR PREPARING PHENYLTHIOMETHYL-THIAZOLES OR OXAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159598-A1 | Process for preparation of chemical compounds | PPARA, PPARG, PPARD | PPARD 3/4885PPARA 1/4885PPARG 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.