Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093152 | 1.00 | PTGS2 (0.42) | PTGS2JAK2HDAC6PTGS1 | |
| SCHEMBL5738793 | 0.75 | PTGS2 (0.49) | PTGS2HDAC6PTGS1 | |
| SCHEMBL3401229 | 0.74 | JAK2 (0.45) | PTGS2JAK2HDAC6PTGS1 | |
| SCHEMBL23093187 | 0.72 | PTGS2 (0.45) | PTGS2JAK2HDAC6 | |
| SCHEMBL23093379 | 0.71 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL23093167 | 0.71 | PTGS2 (0.42) | PTGS2JAK2HDAC6 | |
| SCHEMBL23093039 | 0.71 | PTGS2 (0.42) | PTGS2JAK2HDAC6 | |
| SCHEMBL23093041 | 0.71 | PTGS2 (0.42) | PTGS2JAK2HDAC6 | |
| SCHEMBL2336025 | 0.69 | PTGS2 (0.45) | PTGS2 | |
| SCHEMBL1657463 | 0.68 | JAK2 (0.65) | PTGS2JAK2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4027993-A1 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | The Broad Institute Inc. (US) | 2022-07-20 | — | — | EP | disclosed |