Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.36 |
| ▸ | CASP1 | P29466 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CASP7 | P55210 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23093442 | 1.00 | FGFR1 (0.40) | FGFR1FGFR4ALDH1A1HPGDKDM4E | |
| SCHEMBL23093469 | 0.82 | CYP1A2 (0.43) | FGFR1FGFR4ALDH1A1HPGDTSHR | |
| SCHEMBL23093463 | 0.80 | CYP1A2 (0.40) | ALDH1A1HPGDKDM4ESMN1; SMN2TSHR | |
| SCHEMBL23093159 | 0.78 | DRD4 (0.38) | HPGDKDM4ESMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL29802514 | 0.78 | DRD4 (0.38) | HPGDKDM4ESMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL9798126 | 0.72 | HDAC6 (0.53) | — | |
| SCHEMBL9674199 | 0.72 | CYP11B1 (0.58) | ALDH1A1HPGDKDM4ESMN1; SMN2POLB | |
| SCHEMBL29802500 | 0.70 | NR3C1 (0.43) | ALDH1A1HPGDKDM4ESMN1; SMN2TSHR | |
| SCHEMBL23093119 | 0.70 | NR3C1 (0.43) | ALDH1A1HPGDKDM4ESMN1; SMN2TSHR | |
| SCHEMBL31720305 | 0.70 | FGFR1 (0.42) | FGFR1FGFR4SMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4027993-A1 | CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF | The Broad Institute Inc. (US) | 2022-07-20 | — | — | EP | disclosed |