Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 7/20 | 0.32 |
| ▸ | DRD2 | P14416 | 5/20 | 0.31 |
| ▸ | HTR2A | P28223 | 4/20 | 0.31 |
| ▸ | DRD3 | P35462 | 4/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300048 | 0.80 | KCNJ1 (0.35) | KCNJ1DRD4HTR1DDRD2HTR2A | |
| SCHEMBL2897011 | 0.80 | KCNJ1 (0.42) | KCNJ1DRD4HTR1DNOTUMDRD2 | |
| SCHEMBL2732158 | 0.78 | GPR119 (0.42) | KCNJ1 | |
| SCHEMBL297981 | 0.75 | KCNJ1 (0.41) | KCNJ1HTR1DDRD2HTR2A | |
| SCHEMBL2732161 | 0.75 | KCNJ1 (0.37) | KCNJ1DRD4HTR1DNOTUMAR | |
| SCHEMBL13028033 | 0.72 | KCNJ1 (0.38) | KCNJ1DRD4DRD2 | |
| SCHEMBL297794 | 0.69 | DRD1 (0.43) | DRD4HTR1DNOTUMDRD2 | |
| SCHEMBL2732340 | 0.69 | GPR119 (0.40) | — | |
| SCHEMBL16682216 | 0.68 | KCNJ1 (0.44) | KCNJ1 | |
| SCHEMBL19812920 | 0.68 | SLC6A4 (0.39) | DRD4NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129379-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |