Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904104 | 1.00 | MRGPRX1 (0.38) | MRGPRX1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL13460085 | 0.82 | HTT (0.42) | MRGPRX1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL28381075 | 0.77 | HTT (0.40) | MRGPRX1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL1899302 | 0.77 | MRGPRX1 (0.38) | MRGPRX1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL27023187 | 0.74 | RAB9A (0.38) | MRGPRX1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL25636165 | 0.74 | MRGPRX1 (0.36) | MRGPRX1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL1604974 | 0.72 | MRGPRX1 (0.46) | MRGPRX1HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL25030030 | 0.71 | HTR2A (0.44) | — | |
| SCHEMBL25028223 | 0.71 | HTR2A (0.41) | HTTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL1330351 | 0.71 | PDPK1 (0.44) | HTTRAB9APKMSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4277892-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | Les Laboratoires Servier (FR) | 2023-11-22 | — | — | EP | disclosed |
| WO-2022152705-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-07-21 | — | — | WO | disclosed |