Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23144274 | 1.00 | MAPT (0.51) | MAPTKDM4ETDP1BLMMEN1 | |
| SCHEMBL4374371 | 0.78 | KDM4E (0.55) | MAPTKDM4ETDP1BLMMEN1 | |
| SCHEMBL28215127 | 0.74 | TDP1 (0.56) | MAPTKDM4ETDP1BLMMEN1 | |
| SCHEMBL4384056 | 0.73 | MEN1 (0.47) | MAPTKDM4ETDP1BLMMEN1 | |
| SCHEMBL29396391 | 0.72 | TDP1 (0.62) | MAPTKDM4ETDP1BLMMEN1 | |
| SCHEMBL1179747 | 0.72 | TDP1 (0.62) | MAPTKDM4ETDP1BLMMEN1 | |
| SCHEMBL12778105 | 0.70 | KMT2A (0.53) | MAPTKDM4EMEN1KMT2AMTNR1A | |
| SCHEMBL7483015 | 0.69 | MEN1 (0.54) | MAPTKDM4ETDP1BLMMEN1 | |
| SCHEMBL31254142 | 0.69 | CTSV (0.60) | MAPTTDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL17950573 | 0.69 | MAPT (0.48) | MAPTKDM4ETDP1BLMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034104-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION | PMV Pharmaceuticals, Inc. (US) | 2022-08-03 | — | — | EP | disclosed |