Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 1.00 |
| ▸ | JAK1 | P23458 | 16/20 | 1.00 |
| ▸ | JAK2 | O60674 | 11/20 | 1.00 |
| ▸ | TYK2 | P29597 | 2/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28876022 | 1.00 | JAK3 (1.00) | JAK3JAK1JAK2TYK2EGFR | |
| SCHEMBL29813686 | 0.91 | JAK3 (1.00) | JAK3JAK1JAK2TYK2EGFR | |
| SCHEMBL28875990 | 0.91 | JAK3 (1.00) | JAK3JAK1JAK2TYK2EGFR | |
| SCHEMBL28876008 | 0.88 | JAK3 (1.00) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL29813733 | 0.88 | JAK3 (1.00) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28876026 | 0.86 | JAK3 (0.75) | JAK3JAK1JAK2TYK2EGFR | |
| Morpholine SCHEMBL28329002 | 0.82 | JAK3 (0.70) | JAK3JAK1JAK2TYK2EGFR | |
| SCHEMBL28875992 | 0.80 | JAK2 (1.00) | JAK3JAK1JAK2TYK2EGFR | |
| SCHEMBL29813742 | 0.80 | JAK2 (1.00) | JAK3JAK1JAK2TYK2EGFR | |
| SCHEMBL28875984 | 0.79 | JAK3 (1.00) | JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |