Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.54 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 9/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23071318 | 1.00 | AXL (0.54) | AXLALOX5APFEN1CSF1RPDGFRA | |
| SCHEMBL21426333 | 0.83 | CSF1R (0.49) | AXLCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL30890867 | 0.83 | CSF1R (0.49) | AXLCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL29736560 | 0.81 | CSF1R (0.55) | AXLCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL2418677 | 0.81 | CSF1R (0.55) | AXLCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL23070996 | 0.80 | AXL (0.55) | AXLCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL29736783 | 0.80 | AXL (0.55) | AXLCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL23071332 | 0.76 | AXL (0.51) | AXLCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL21772041 | 0.75 | CSF1R (0.47) | AXLCSF1RPDGFRAPDGFRBFLT3 | |
| SCHEMBL2412873 | 0.71 | AXL (0.45) | AXLALOX5APFEN1CSF1RPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283916-B | Compound with Axl and c-Met kinase inhibition activity and preparation and application thereof | 中国科学院上海药物研究所 | 2024-06-11 | — | — | CN | disclosed |
| CN-116283916-A | Compound with Axl and c-Met kinase inhibition activity and preparation and application thereof | 中国科学院上海药物研究所 | 2023-06-23 | — | — | CN | disclosed |
| CN-112457295-B | Compound with Axl and c-Met kinase inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2022-07-26 | — | — | CN | disclosed |