Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.55 |
| ▸ | CSF1R | P07333 | 12/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | MET | P08581 | 4/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29736783 | 1.00 | AXL (0.55) | AXLCSF1RPDGFRAFLT3MET | |
| SCHEMBL23081321 | 0.85 | AXL (0.60) | AXLCSF1RPDGFRAFLT3MET | |
| SCHEMBL2418677 | 0.83 | CSF1R (0.55) | AXLCSF1RPDGFRAFLT3MET | |
| SCHEMBL29736560 | 0.83 | CSF1R (0.55) | AXLCSF1RPDGFRAFLT3MET | |
| SCHEMBL29814290 | 0.80 | AXL (0.54) | AXLCSF1RPDGFRAFLT3MET | |
| SCHEMBL23071318 | 0.80 | AXL (0.54) | AXLCSF1RPDGFRAFLT3MET | |
| SCHEMBL2539404 | 0.79 | MET (0.47) | AXLMETKDREGFR | |
| SCHEMBL828141 | 0.77 | AXL (0.62) | AXLCSF1RPDGFRAFLT3MET | |
| SCHEMBL828378 | 0.77 | AXL (0.59) | AXLCSF1RPDGFRAFLT3MET | |
| SCHEMBL23071332 | 0.76 | AXL (0.51) | AXLCSF1RPDGFRAFLT3MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021043217-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2021-03-11 | — | — | WO | disclosed |
| WO-2021043217-A1 | COMPOUND HAVING AXL AND C-MET KINASE INHIBITORY ACTIVITY, PREPARATION THEREOF AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2021-03-11 | — | — | WO | disclosed |