Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.57 |
| ▸ | BTK | Q06187 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | TEK | Q02763 | 7/20 | 0.56 |
| ▸ | LCK | P06239 | 5/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29099018 | 1.00 | EGFR (0.57) | EGFRBTKKDRTEKLCK | |
| SCHEMBL29817882 | 0.88 | EGFR (0.71) | EGFRBTKKDRTEKLCK | |
| SCHEMBL29098961 | 0.88 | EGFR (0.71) | EGFRBTKKDRTEKLCK | |
| SCHEMBL29098950 | 0.87 | KDR (0.61) | EGFRBTKKDRTEKLCK | |
| SCHEMBL29818017 | 0.87 | KDR (0.61) | EGFRBTKKDRTEKLCK | |
| SCHEMBL29817964 | 0.85 | EGFR (0.65) | EGFRBTKKDRTEKLCK | |
| SCHEMBL29098975 | 0.85 | EGFR (0.65) | EGFRBTKKDRTEKLCK | |
| SCHEMBL29098988 | 0.79 | EGFR (0.65) | EGFRBTK | |
| SCHEMBL29817807 | 0.77 | EGFR (0.64) | EGFRBTK | |
| SCHEMBL2073296 | 0.75 | KDR (0.76) | EGFRKDRTEKLCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573586-B | Polycyclic compound for inhibiting Bruton tyrosine kinase activity, pharmaceutical composition and application thereof | 杭州和正医药有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-114573586-A | Polycyclic compound for inhibiting Bruton's tyrosine kinase activity, pharmaceutical composition and application thereof | 杭州和正医药有限公司 | 2022-06-03 | — | — | CN | disclosed |