Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.61 |
| ▸ | TEK | Q02763 | 7/20 | 0.61 |
| ▸ | LCK | P06239 | 5/20 | 0.61 |
| ▸ | EGFR | P00533 | 12/20 | 0.60 |
| ▸ | BTK | Q06187 | 6/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29098950 | 1.00 | KDR (0.61) | KDRTEKLCKEGFRBTK | |
| SCHEMBL29098961 | 0.92 | EGFR (0.71) | KDRTEKLCKEGFRBTK | |
| SCHEMBL29817882 | 0.92 | EGFR (0.71) | KDRTEKLCKEGFRBTK | |
| SCHEMBL29099018 | 0.87 | EGFR (0.57) | KDRTEKLCKEGFRBTK | |
| SCHEMBL29817822 | 0.87 | EGFR (0.57) | KDRTEKLCKEGFRBTK | |
| SCHEMBL29817964 | 0.83 | EGFR (0.65) | KDRTEKLCKEGFRBTK | |
| SCHEMBL29098975 | 0.83 | EGFR (0.65) | KDRTEKLCKEGFRBTK | |
| SCHEMBL2072241 | 0.77 | TEK (0.81) | KDRTEKLCKEGFRSRC | |
| SCHEMBL29098988 | 0.77 | EGFR (0.65) | EGFRBTK | |
| SCHEMBL2074526 | 0.76 | TEK (0.86) | KDRTEKLCKEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573586-B | Polycyclic compound for inhibiting Bruton tyrosine kinase activity, pharmaceutical composition and application thereof | 杭州和正医药有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-114573586-A | Polycyclic compound for inhibiting Bruton's tyrosine kinase activity, pharmaceutical composition and application thereof | 杭州和正医药有限公司 | 2022-06-03 | — | — | CN | disclosed |