Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 15/20 | 0.34 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24666304 | 1.00 | CFD (0.34) | CFDPSMB9DRD2XIAPMAPK1 | |
| SCHEMBL24665687 | 0.89 | CFD (0.36) | CFDPSMB9DRD2 | |
| SCHEMBL29230886 | 0.89 | CFD (0.36) | CFDPSMB9DRD2 | |
| SCHEMBL29820441 | 0.87 | PSMB9 (0.34) | CFDPSMB9DRD2 | |
| SCHEMBL24664621 | 0.87 | PSMB9 (0.34) | CFDPSMB9DRD2 | |
| SCHEMBL24666302 | 0.87 | CFD (0.35) | CFDPSMB9XIAP | |
| SCHEMBL29820129 | 0.87 | CFD (0.35) | CFDPSMB9XIAP | |
| SCHEMBL24666299 | 0.87 | CFD (0.34) | CFDPSMB9XIAP | |
| SCHEMBL29231430 | 0.87 | CFD (0.34) | CFDPSMB9XIAP | |
| SCHEMBL26833067 | 0.86 | CFD (0.40) | CFDDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308095-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | Maze Therapeutics, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |