Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25822816 | 1.00 | PDE3B (0.42) | PDE3BPDE3AP2RY12THRATHRB | |
| SCHEMBL25298753 | 0.88 | PDK2 (0.46) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL24675148 | 0.85 | PDE3B (0.44) | PDE3BPDE3AP2RY12PDE2A | |
| Hydrochloric Acid SCHEMBL25245928 | 0.84 | PDE3B (0.43) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL24675640 | 0.83 | CA12 (0.40) | PDE3BPDE3AP2RY12THRATHRB | |
| SCHEMBL29823274 | 0.83 | CA12 (0.40) | PDE3BPDE3AP2RY12THRATHRB | |
| Hydrochloric Acid SCHEMBL25437928 | 0.79 | PDK2 (0.40) | PDE3BPDE3AP2RY12THRATHRB | |
| SCHEMBL24675523 | 0.78 | LTA4H (0.47) | PDE3BPDE3AP2RY12HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL25250800 | 0.77 | LTA4H (0.46) | PDE3BPDE3AP2RY12HDAC1HDAC2 | |
| SCHEMBL24675766 | 0.76 | CNR1 (0.47) | PDE3BPDE3AP2RY12HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| EP-4281445-A1 | DEGRADERS OF GRK2 AND USES THEREOF | Sonata Therapeutics, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |