Tamsulosin

Tamsulosin

SCHEMBL29823016

CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1.Cl

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1D

The experimentally established mechanism targets of Tamsulosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A known ✓ P35348 10/20 0.98
ADRA1D known ✓ P25100 9/20 0.98
ADRA1B known ✓ P35368 9/20 0.98
ADRB2 P07550 4/20 0.98
ADRB1 P08588 2/20 0.98
HTR1A P08908 2/20 0.98
ADRA2A P08913 2/20 0.98
DRD2 P14416 2/20 0.98
ADRA2B P18089 2/20 0.98
ADRA2C P18825 2/20 0.98
HTR2A P28223 2/20 0.98
DRD3 P35462 2/20 0.98
HTR2B P41595 2/20 0.98
KCNH2 Q12809 2/20 0.98
HTR7 P34969 1/20 0.98
OPRM1 P35372 1/20 0.98
SIGMAR1 Q99720 2/20 0.52
SLC6A4 P31645 1/20 0.43
HRH1 P35367 1/20 0.43
PDE4D Q08499 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tamsulosin SCHEMBL29641643 1.00 ADRA1A (0.98) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL3397438 1.00 ADRA1A (0.98) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL2319987 1.00 ADRA1A (0.98) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL29625170 1.00 ADRA1A (0.98) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL1560198 1.00 ADRA1A (0.98) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL2315085 1.00 ADRA1A (0.98) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL23428 1.00 ADRA1A (0.98) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL9300408 1.00 ADRA1A (0.98) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL356385 0.99 ADRA1A (0.96) ADRA1AADRA1DADRA1BADRB2ADRB1
Tamsulosin SCHEMBL11815414 0.99 ADRA1A (0.96) ADRA1AADRA1DADRA1BADRB2ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240216584-A1 METHODS, SYSTEMS, AND DEVICES FOR GENERATING DEFINED FIBER CONSTRUCTS NATIONAL INSTITUTES OF HEALTH 2024-07-04 US disclosed
US-20230330157-A1 MODULATION OF MICROBIOTA FUNCTION BY GENE THERAPY OF THE MICROBIOME TO PREVENT, TREAT OR CURE MICROBIOME-ASSOCIATED DISEASES OR DISORDERS ELIGO BIOSCIENCE (FR) 2023-10-19 US disclosed
US-11690880-B2 Modulation of microbiota function by gene therapy of the microbiome to prevent, treat or cure microbiome-associated diseases or disorders ELIGO BIOSCIENCE (FR) 2023-07-04 US disclosed
US-20230126159-A1 ENGINEERED BACTERIAL STRAINS COMPRISING A TRANSGENE ELIGO BIOSCIENCE (FR) 2023-04-27 US disclosed
WO-2023057598-A1 METHODS INVOLVING BACTERIAL STRAIN REPLACEMENT ELIGO BIOSCIENCE (FR) 2023-04-13 WO disclosed
US-20230113800-A1 MODULATION OF MICROBIOTA FUNCTION BY GENE THERAPY OF THE MICROBIOME TO PREVENT, TREAT OR CURE MICROBIOME-ASSOCIATED DISEASES OR DISORDERS ELIGO BIOSCIENCE (FR) 2023-04-13 US disclosed
US-20230114520-A1 ENGINEERED BIFIDOBACTERIUM STRAINS COMPRISING A TRANSGENE ELIGO BIOSCIENCE (FR) 2023-04-13 US disclosed
US-11534467-B2 Modulation of microbiota function by gene therapy of the microbiome to prevent, treat or cure microbiome-associated diseases or disorders ELIGO BIOSCIENCE (FR) 2022-12-27 US disclosed
WO-2021204967-A9 MODULATION OF MICROBIOTA FUNCTION BY GENE THERAPY OF THE MICROBIOME TO PREVENT, TREAT OR CURE MICROBIOME-ASSOCIATED DISEASES OR DISORDERS ELIGO BIOSCIENCE (FR) 2022-11-10 WO disclosed
EP-4069840-A1 MODULATION OF MICROBIOTA FUNCTION BY GENE THERAPY OF THE MICROBIOME TO PREVENT, TREAT OR CURE MICROBIOME-ASSOCIATED DISEASES OR DISORDERS Eligo Bioscience (FR) 2022-10-12 EP disclosed
WO-2022192517-A1 METHODS, SYSTEMS, AND DEVICES FOR GENERATING DEFINED FIBER CONSTRUCTS ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2022-09-15 WO disclosed
US-20220233610-A1 MODULATION OF MICROBIOTA FUNCTION BY GENE THERAPY OF THE MICROBIOME TO PREVENT, TREAT OR CURE MICROBIOME-ASSOCIATED DISEASES OR DISORDERS ELIGO BIOSCIENCE (FR) 2022-07-28 US disclosed