Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | CLK2 | P49760 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28960259 | 0.80 | DYRK1A (0.45) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL23726765 | 0.76 | AURKA (0.41) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL1192302 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL31588150 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL24659326 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL30280407 | 0.72 | CHEK1 (0.45) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL1565081 | 0.72 | CHEK1 (0.45) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL7513614 | 0.72 | CHEK1 (0.45) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL10131569 | 0.72 | DYRK1A (0.46) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 | |
| SCHEMBL6667192 | 0.71 | LMNA (0.56) | SMN1; SMN2AURKAJAK2MAP4K4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116546985-A | Pyridopyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022160931-A1 | PYRIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2022-08-04 | — | — | WO | disclosed |