Meglitinide

Meglitinide

SCHEMBL29829482

COc1ccc(Cl)cc1C(=O)NCCc1ccc(C(=O)O)cc1

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DNMT3A Q9Y6K1 1/20 0.78
HDAC1 Q13547 2/20 0.72
HDAC6 Q9UBN7 2/20 0.72
NLRP3 Q96P20 3/20 0.71
GAA P10253 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Meglitinide SCHEMBL37926 1.00 DNMT3A (0.78) DNMT3AHDAC1HDAC6NLRP3GAA
SCHEMBL11354611 0.91 DNMT3A (0.75) DNMT3AHDAC1HDAC6NLRP3GAA
SCHEMBL11360335 0.91 DNMT3A (0.78) DNMT3AHDAC1HDAC6NLRP3GAA
SCHEMBL11479096 0.90 HDAC1 (0.71) DNMT3AHDAC1HDAC6NLRP3
SCHEMBL1153776 0.90 DNMT3A (0.67) DNMT3AHDAC1HDAC6NLRP3
SCHEMBL3784241 0.89 DNMT3A (0.80) DNMT3AHDAC1HDAC6NLRP3
SCHEMBL8261934 0.89 DNMT3A (0.84) DNMT3AHDAC1HDAC6NLRP3
SCHEMBL1154792 0.88 DNMT3A (0.62) DNMT3AHDAC1HDAC6NLRP3GAA
SCHEMBL30381560 0.88 HDAC1 (0.79) DNMT3AHDAC1HDAC6NLRP3
SCHEMBL11481071 0.88 HDAC1 (0.79) DNMT3AHDAC1HDAC6NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4192831-B1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO INC (US) 2025-10-22 EP claimed
EP-3758692-B1 COMPOSITIONS AND METHODS FOR TREATING PAIN UNIV MARYLAND (US) 2024-08-21 EP claimed
EP-3782996-B1 NRF2 REGULATORS GLAXOSMITHKLINE IP DEV LTD (GB) 2024-04-10 EP claimed
EP-3328388-B1 A PHARMACEUTICAL PREPARATION FOR IMPROVING ABSORPTION AND POSTPRANDIAL HYPOGLYCEMIC ACTION OF INSULIN LILLY CO ELI (US) 2023-12-27 EP claimed
EP-3164125-B1 METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES NAN GLOBAL LLC (US) 2023-09-06 EP claimed
CN-116437914-A Glucokinase activators for the treatment of diabetes with liver injury 华领医药技术(上海)有限公司 2023-07-14 CN claimed
EP-3628101-B1 METHOD AND SYSTEM FOR MANAGING LIFESTYLE AND HEALTH INTERVENTIONS BETTER THERAPEUTICS LLC (US) 2023-06-07 EP claimed
EP-3432877-B1 D-ALPHA-METHYLDOPA FOR TREATING AUTOIMMUNE DISEASE IMMUNOMOLECULAR THERAPEUTICS INC (US) 2023-01-11 EP claimed
EP-3359162-B1 METHODS OF TREATING INJURIES OR CONDITIONS RELATED TO CNS EDEMA BIOGEN CHESAPEAKE LLC (US) 2022-12-21 EP claimed
EP-3302458-B1 METHODS OF PREVENTING AND TREATING AUTOIMMUNITY UNIV COLORADO REGENTS (US) 2022-09-07 EP claimed
EP-3801542-B1 METHODS OF TREATING SUBJECTS HAVING DIABETES WITH CHRONIC KIDNEY DISEASE POXEL SA (FR) 2022-08-10 EP claimed
CN-120018857-A Combination therapy of GPRC5D TCB and IMID 豪夫迈·罗氏有限公司 2025-05-16 CN disclosed
CN-119470873-A Biomarkers for metabolic syndrome 佐拉生物科学公司 2025-02-18 CN disclosed
CN-118955413-A Emamiger hydrochloride preparation method of LIMING 宁夏恒康科技有限公司 2024-11-15 CN disclosed
CN-118159654-A Inhibin subunit beta E (INHBE) modulator compositions and methods of use thereof 阿尔尼拉姆医药品有限公司 2024-06-07 CN disclosed
EP-3826627-B1 ORALLY ADMINISTERABLE PHARMACEUTICAL DOSAGE FORM WITH MODIFIED RELEASE BAYER AG (DE) 2023-10-18 EP disclosed
CN-116769054-A Bispecific signaling agents and uses thereof 奥里尼斯生物科学私人有限公司 2023-09-19 CN disclosed
CN-116437914-A Glucokinase activators for the treatment of diabetes with liver injury 华领医药技术(上海)有限公司 2023-07-14 CN disclosed
CN-109071663-B Bispecific signaling agents and uses thereof 奥里尼斯生物科学私人有限公司 2023-07-04 CN disclosed
CN-111171047-B Fused dihydro-4H-pyrazolo [5,1-C ] [1,4] oxazinyl compounds for the treatment of CNS disorders 赛诺维信制药公司 2023-06-23 CN disclosed