Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 6/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26650949 | 1.00 | AXL (0.39) | AXLTRPA1PTPN6TRPM8TRPV1 | |
| SCHEMBL22805892 | 0.78 | HTT (0.38) | AXLHTTPTK2METAP2NOS1 | |
| SCHEMBL29366423 | 0.78 | HTT (0.38) | AXLHTTPTK2METAP2NOS1 | |
| SCHEMBL30468824 | 0.77 | HTT (0.33) | AXLTRPA1HTTPTK2METAP2 | |
| SCHEMBL24494919 | 0.77 | HTT (0.33) | AXLTRPA1HTTPTK2METAP2 | |
| SCHEMBL31021511 | 0.75 | AXL (0.50) | AXLTRPA1PTPN6TRPM8TRPV1 | |
| SCHEMBL22805867 | 0.75 | NOS1 (0.38) | AXLHTTPTK2NOS1IDO1 | |
| SCHEMBL31393062 | 0.75 | NOS1 (0.38) | AXLHTTPTK2NOS1IDO1 | |
| SCHEMBL29780192 | 0.71 | AXL (0.46) | AXLTRPA1PTPN6TRPM8TRPV1 | |
| SCHEMBL3497499 | 0.71 | AXL (0.46) | AXLTRPA1PTPN6TRPM8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522617-A1 | NEW INDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-03-19 | — | — | EP | disclosed |
| CN-119173518-A | Indazole derivatives | 豪夫迈·罗氏有限公司 | 2024-12-20 | — | — | CN | disclosed |
| WO-2023217923-A1 | NEW INDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-11-16 | — | — | WO | disclosed |
| EP-4255908-A1 | NEW INDAZOLE ACETYLENE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-10-11 | — | — | EP | disclosed |
| CN-116490182-A | Indazole acetylene derivatives | 豪夫迈·罗氏有限公司 | 2023-07-25 | — | — | CN | disclosed |
| WO-2022117477-A1 | NEW INDAZOLE ACETYLENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-06-09 | — | — | WO | disclosed |