Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 6/20 | 0.50 |
| ▸ | NOS2 | P35228 | 5/20 | 0.50 |
| ▸ | NOS3 | P29474 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28448456 | 1.00 | MAPT (0.53) | MAPTRAB9AMEN1KMT2APKM | |
| SCHEMBL9362872 | 0.87 | NOS1 (0.56) | NOS1NOS2NOS3PRSS1PRSS2 | |
| SCHEMBL9362866 | 0.87 | NOS1 (0.56) | NOS1NOS2NOS3PRSS1PRSS2 | |
| SCHEMBL10119256 | 0.86 | MAPT (0.50) | MAPTRAB9AMEN1KMT2APKM | |
| SCHEMBL28448458 | 0.84 | MEN1 (0.55) | MAPTRAB9AMEN1KMT2ANOS1 | |
| SCHEMBL29832640 | 0.84 | MEN1 (0.55) | MAPTRAB9AMEN1KMT2ANOS1 | |
| SCHEMBL12653890 | 0.81 | MAPT (0.64) | MAPTRAB9AMEN1KMT2APKM | |
| SCHEMBL11328779 | 0.80 | KMT2A (0.73) | MAPTRAB9AMEN1KMT2APKM | |
| SCHEMBL11696992 | 0.80 | KMT2A (0.73) | MAPTRAB9AMEN1KMT2APKM | |
| SCHEMBL30403224 | 0.78 | NOS1 (0.43) | MAPTRAB9AMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111467500-B | Low-oxygen dual-targeting AGT inhibitor conjugate and preparation method and application thereof | 北京工业大学 | 2022-08-09 | — | — | CN | disclosed |